Researchers have found that the drug rilmenidine can extend lifespan and slow aging.
Posted in aging celll, results show that animals treated with rilmenidine, currently used to treat hypertension, at young and older ages increase lifespan and improve health markers, mimicking the effects of calorie restriction.
They also demonstrate that the health and lifespan benefits of rilmenidine treatment in roundworms C.elegans are mediated by the I1-imidazoline nish-1 receptor, identifying this receptor as a potential longevity target.
Unlike other drugs previously studied for this purpose by researchers, rilmenidine, a widely prescribed oral antihypertensive, has potential for future translation into humans, as side effects are rare and not serious.
To date, a calorie restriction diet has been considered the most robust anti-aging intervention, promoting longevity across species. However, studies of calorie restriction in humans have had mixed results and side effects, meaning finding drugs like rilmenidine that can mimic the benefits of calorie restriction is the most reasonable anti-aging strategy. .
Professor João Pedro Magalhães, who led the research at the University of Liverpool and is now based at the University of Birmingham, said: “With an aging global population, the benefits of delaying ageing, even slightly, are immense. . to extend lifespan and lifespan has enormous untapped potential in translational geroscience. For the first time, we were able to show in animals that rilmenidine can increase lifespan. We now wish to explore whether rilmenidine may have other clinical applications.
This study was undertaken by researchers from the University of Liverpool, ETH Zürich and Harvard Medical School, and funded by the Swiss National Science Foundation, LongeCity and the Biotechnology and Biological Sciences Research Council.